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KMID : 0605620150220040173
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Journal of Korean Society of Biological Psychiatry
2015 Volume.22 No. 4 p.173 ~ p.178
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Association Study of ANK3 Polymorphism and Risk of Schizophrenia
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양소영:Yang So-Yung
허익수:Huh Ik-Soo/조은영:Cho Eun-Young/최미지:Choi Mi-Ji/박태성:Park Tae-Sung/이유상:Lee Yu-Sang/홍경수:Hong Kyung-Sue
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Abstract
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Objectives : Previous genome-wide association studies have indicated the association between ankyrin 3 (ANK3) and the vulnerability of schizophrenia. We investigated the association between single nucleotide polymorphisms (SNPs) covering the whole ANK3 locus and schizophrenia in the Korean population.
Methods : The study subjects were 582 patients with schizophrenia and 502 healthy controls. Thirty-eight tag SNPs on ANK3 and five additional SNPs showing significant association with schizophrenia in previous studies were genotyped.
Results : Three (rs10994181, rs16914791, rs1938526) of 43 SNPs showed a nominally significant association (p < 0.05) with at least one genotype model. But none of these associations remained significant after adjusting for multiple testing errors with Bonferroni's correction.
Conclusions : We could not identify a significant association between ANK3 and schizophrenia in the Korean population. However, three SNPs showing an association signal with nominal significance need to be investigated in future studies with higher statistical power and more specific phenotype crossing the current diagnostic categories.
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KEYWORD
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ANK3, Schizophrenia, Genetic association study
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